Description
Product Characteristics:
Heparanase is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasations of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and an 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival.
Subcellular location: Cytoplasm, Nucleus, Secreted, Cell membrane, Extracellular matrix
Synonyms: Heparanase 50 kDa subunit, heparanase, heparanase1, heparanase-1, heparanase 1, Endo glucoronidase, Endo glucoronidase, Endo-glucoronidase, HPSE_HUMAN, Heparanase1, Heparanase 1, HEP, Hpa 1, HPA, Hpa1, HPR 1, HPR1, HPSE 1, HPSE, HPSE1, HSE 1, HSE1.
Target Information: Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]